Myxopyronin A
| Code | Size | Price |
|---|
| TAR-T24514-5mg | 5mg | £1,091.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24514-50mg | 50mg | £2,143.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24514-100mg | 100mg | £2,801.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Myxopyronin A is an inhibitor of bacterial RNA polymerase.
CAS:
88192-98-7
Formula:
C23H31NO6
Molecular Weight:
417.502
Purity:
0.98
SMILES:
CCCC(C)=CC=C(/C)C(O)=C1/C(=O)OC(=CC1=O)[C@H](C)CCC=CNC(=O)OC
References
1. Molodtsov V, Fleming PR, Eyermann CJ, Ferguson AD, Foulk MA, McKinney DC, Masse CE, Buurman ET, Murakami KS. X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein. J Med Chem. 2015 Apr 9;58(7):3156-71. doi: 10.1021/acs.jmedchem.5b00050. Epub 2015 Mar 23. PubMed PMID: 25798859; PubMed Central PMCID: PMC4658208.
2. Fruth M, Plaza A, Hinsberger S, Sahner JH, Haupenthal J, Bischoff M, Jansen R, M?ller R, Hartmann RW. Binding mode characterization of novel RNA polymerase inhibitors using a combined biochemical and NMR approach. ACS Chem Biol. 2014 Nov 21;9(11):2656-63. doi: 10.1021/cb5005433. Epub 2014 Sep 26. PubMed PMID: 25207839.
3. Jeong YC, Bikadi Z, Hazai E, Moloney MG. A detailed study of antibacterial 3-acyltetramic acids and 3-acylpiperidine-2,4-diones. ChemMedChem. 2014 Aug;9(8):1826-37. doi: 10.1002/cmdc.201402093. Epub 2014 May 18. PubMed PMID: 24838989.
4. Sucipto H, Wenzel SC, M?ller R. Exploring chemical diversity of ?-pyrone antibiotics: molecular basis of myxopyronin biosynthesis. Chembiochem. 2013 Sep 2;14(13):1581-9. doi: 10.1002/cbic.201300289. Epub 2013 Aug 26. PubMed PMID: 23983106.