Pentachloropseudilin
| Code | Size | Price |
|---|
| TAR-T24612-5mg | 5mg | £724.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24612-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24612-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Pentachloropseudilin is a selective inhibitor of Myosin-1. In target cells, It acts by suppressing transforming growth factor-β activity by accelerating cell-surface type II TGF-β receptor turnover.
CAS:
69640-38-6
Formula:
C10H4Cl5NO
Molecular Weight:
331.4
Purity:
0.98
SMILES:
Oc1c(Cl)cc(Cl)cc1-c1[nH]c(Cl)c(Cl)c1Cl
References
1. Chung CL, Wang SW, Martin R, Kn?lker HJ, Kao YC, Lin MH, Chen JJ, Huang YB, Wu DC, Chen CL. Pentachloropseudilin inhibits transforming growth factor-? (TGF-?) activity by accelerating cell-surface type II TGF-? receptor turnover in target cells. Chembiochem. 2018 Jan 25. doi: 10.1002/cbic.201700693. [Epub ahead of print] PubMed PMID: 29369495.
2. Gupta P, Martin R, Kn?lker HJ, Nihalani D, Kumar Sinha D. Myosin-1 inhibition by PClP affects membrane shape, cortical actin distribution and lipid droplet dynamics in early Zebrafish embryos. PLoS One. 2017 Jul 5;12(7):e0180301. doi: 10.1371/journal.pone.0180301. eCollection 2017. PubMed PMID: 28678859; PubMed Central PMCID: PMC5498032.
3. Rozbicki E, Chuai M, Karjalainen AI, Song F, Sang HM, Martin R, Kn?lker HJ, MacDonald MP, Weijer CJ. Myosin-II-mediated cell shape changes and cell intercalation contribute to primitive streak formation. Nat Cell Biol. 2015 Apr;17(4):397-408. doi: 10.1038/ncb3138. PubMed PMID: 25812521; PubMed Central PMCID: PMC4886837.
4. Brandstaetter H, Kishi-Itakura C, Tumbarello DA, Manstein DJ, Buss F. Loss of functional MYO1C/myosin 1c, a motor protein involved in lipid raft trafficking, disrupts autophagosome-lysosome fusion. Autophagy. 2014;10(12):2310-23. doi: 10.4161/15548627.2014.984272. PubMed PMID: 25551774; PubMed Central PMCID: PMC4502697.