PF04677490
Code | Size | Price |
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TAR-T24615-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T24615-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T24615-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
PF04677490 is an effective PDE1 inhibitor. PF04677490 efficaciously inhibits cAMP- and cGMP-hydrolytic activity in preparations from human myocardium at concentrations selective for PDE1.
CAS:
1628342-10-8
Formula:
C17H21N5O2
Molecular Weight:
327.388
Purity:
0.98
SMILES:
COc1ccc2c(NC(C)Cc3cc(C)[nH]n3)ncnc2c1OC
References
1. Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1 John M. Humphrey, Matthew Movsesian, Christopher W. am Ende, Stacey L. Becker, Thomas A. Chappie, Stephen Jenkinson, Jennifer L. Liras, Spiros Liras, Christine Orozco, Jayvardhan Pandit, Felix F. Vajdos, Fabrice Vandeput, Eddie Yang, and Frank S. Menniti Publication Date (Web): May 2, 2018 (Brief Article) doi: 10.1021/acs.jmedchem.8b00374