PK-THPP
Code | Size | Price |
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TAR-T24648-5mg | 5mg | £930.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T24648-50mg | 50mg | £1,821.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T24648-100mg | 100mg | £2,319.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
PK-THPP is a channel blocker of TASK-3.
CAS:
1332454-07-5
Formula:
C29H32N4O2
Molecular Weight:
468.601
Purity:
0.98
SMILES:
CCCC(=O)C1CCN(CC1)c1ncnc2CCN(Cc12)C(=O)c1ccc(cc1)-c1ccccc1
References
1. Srisomboon Y, Zaidman NA, Maniak PJ, Deachapunya C, O'Grady SM. P2Y receptor regulation of K2P channels that facilitate K(+) secretion by human mammary epithelial cells. Am J Physiol Cell Physiol. 2018 Jan 24. doi: 10.1152/ajpcell.00342.2016. [Epub ahead of print] PubMed PMID: 29365273.
2. Feng HJ, Faingold CL. Abnormalities of serotonergic neurotransmission in animal models of SUDEP. Epilepsy Behav. 2017 Jun;71(Pt B):174-180. doi: 10.1016/j.yebeh.2015.06.008. Epub 2015 Aug 10. Review. PubMed PMID: 26272185; PubMed Central PMCID: PMC4749463.
3. Zeng C, Long X, Cotten JF, Forman SA, Solt K, Faingold CL, Feng HJ. Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA/1 mice. Epilepsy Behav. 2015 Apr;45:1-7. doi: 10.1016/j.yebeh.2015.02.013. Epub 2015 Mar 13. PubMed PMID: 25771493; PubMed Central PMCID: PMC4424071.
4. Cotten JF. TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats. Anesth Analg. 2013 Apr;116(4):810-6. doi: 10.1213/ANE.0b013e318284469d. Epub 2013 Mar 4. PubMed PMID: 23460565; PubMed Central PMCID: PMC3865919.