Ro 25-6981 HCl
| Code | Size | Price |
|---|
| TAR-T24717-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24717-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24717-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Ro 25-6981 HCl is an effective and selective NMDA glutamate receptors containing the NR2B subunit antagonist.
CAS:
919289-58-0
Formula:
C22H30ClNO2
Molecular Weight:
375.94
Purity:
0.98
SMILES:
Cl.C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1
References
1. Maranis S, Stamatis D, Tsironis C, Konitsiotis S. Investigation of the antidyskinetic site of action of metabotropic and ionotropic glutamate receptor antagonists. Intracerebral infusions in 6-hydroxydopamine-lesioned rats with levodopa-induced dyskinesia. Eur J Pharmacol. 2012 May 15;683(1-3):71-7. doi: 10.1016/j.ejphar.2012.02.036. Epub 2012 Mar 4. PubMed PMID: 22410193.
2. Gagolewicz PJ, Dringenberg HC. NR2B-subunit dependent facilitation of long-term potentiation in primary visual cortex following visual discrimination training of adult rats. Eur J Neurosci. 2011 Oct;34(8):1222-9. doi: 10.1111/j.1460-9568.2011.07842.x. Epub 2011 Sep 6. PubMed PMID: 21895803.
3. Rammes G, Hasenj?ger A, Sroka-Saidi K, Deussing JM, Parsons CG. Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of ?-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices. Neuropharmacology. 2011 May;60(6):982-90. doi: 10.1016/j.neuropharm.2011.01.051. Epub 2011 Feb 12. PubMed PMID: 21310164.
4. Haseneder R, Kratzer S, Kochs E, H?felmann D, Auberson Y, Eder M, Rammes G. The xenon-mediated antagonism against the NMDA receptor is non-selective for receptors containing either NR2A or NR2B subunits in the mouse amygdala. Eur J Pharmacol. 2009 Oct 1;619(1-3):33-7. doi: 10.1016/j.ejphar.2009.08.011. Epub 2009 Aug 15. PubMed PMID: 19686722.