ROCK-IN-D1
| Code | Size | Price |
|---|
| TAR-T24723-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24723-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24723-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
ROCK-IN-D1 is an effective and selective inhibitor of ROCK.
CAS:
1219721-73-9
Formula:
C21H25N5OS
Molecular Weight:
395.53
Purity:
0.98
SMILES:
CN(C)CCSc1cc(ccc1NC(=O)NCc1ccccc1)-c1cn[nH]c1
References
1. Wei J, Huang Q, Bai F, Lin J, Nie J, Lu S, Lu C, Huang R, Lu Z, Lin X. Didymin induces apoptosis through mitochondrial dysfunction and up-regulation of RKIP in human hepatoma cells. Chem Biol Interact. 2017 Jan 5;261:118-126. doi: 10.1016/j.cbi.2016.11.026. Epub 2016 Nov 27. PubMed PMID: 27899290.
2. Qiao F, Zou Z, Liu C, Zhu X, Wang X, Yang C, Jiang T, Chen Y. ROCK2 mediates the proliferation of pulmonary arterial endothelial cells induced by hypoxia in the development of pulmonary arterial hypertension. Exp Ther Med. 2016 Jun;11(6):2567-2572. Epub 2016 Mar 31. PubMed PMID: 27284349; PubMed Central PMCID: PMC4887771.
3. Jiang C, Huang H, Liu J, Wang Y, Zhao Y, Xu Z. [Effects of fasudil on bleomycin-induced pulmonary fibrosis in mice and on the biological behaviors in NIH3T3 mouse fibroblast cell line]. Zhonghua Jie He He Hu Xi Za Zhi. 2014 Sep;37(9):671-6. Chinese. PubMed PMID: 25533689.
4. Shao Q, Kannan A, Lin Z, Stack BC Jr, Suen JY, Gao L. BET protein inhibitor JQ1 attenuates Myc-amplified MCC tumor growth in vivo. Cancer Res. 2014 Dec 1;74(23):7090-102. doi: 10.1158/0008-5472.CAN-14-0305. Epub 2014 Oct 2. PubMed PMID: 25277525; PubMed Central PMCID: PMC4322674.