SAR127303

TargetMol
Product Code: TAR-T24758
Supplier: TargetMol
CodeSizePrice
TAR-T24758-5mg5mg£850.00
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Quantity:
TAR-T24758-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24758-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
SAR127303 is an effective covalent inhibitor of MAGL. SAR127303 behaves as a selective and competitive inhibitor of mouse and human MAGL.
CAS:
1352011-38-1
Formula:
C16H17ClF6N2O4S
Molecular Weight:
482.82
Purity:
0.98
SMILES:
FC(F)(F)C(OC(=O)N1CCC(CNS(=O)(=O)c2ccc(Cl)cc2)CC1)C(F)(F)F

References

1. Wang L, Mori W, Cheng R, Yui J, Hatori A, Ma L, Zhang Y, Rotstein BH, Fujinaga M, Shimoda Y, Yamasaki T, Xie L, Nagai Y, Minamimoto T, Higuchi M, Vasdev N, Zhang MR, Liang SH. Synthesis and Preclinical Evaluation of Sulfonamido-based [(11)C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase. Theranostics. 2016 May 21;6(8):1145-59. doi: 10.7150/thno.15257. eCollection 2016. PubMed PMID: 27279908; PubMed Central PMCID: PMC4893642. 2. Wang C, Placzek MS, Van de Bittner GC, Schroeder FA, Hooker JM. A Novel Radiotracer for Imaging Monoacylglycerol Lipase in the Brain Using Positron Emission Tomography. ACS Chem Neurosci. 2016 Apr 20;7(4):484-9. doi: 10.1021/acschemneuro.5b00293. Epub 2016 Jan 6. PubMed PMID: 26694017. 3. Griebel G, Pichat P, Beesk? S, Leroy T, Redon N, Jacquet A, Fran?on D, Bert L, Even L, Lopez-Grancha M, Tolstykh T, Sun F, Yu Q, Brittain S, Arlt H, He T, Zhang B, Wiederschain D, Bertrand T, Houtmann J, Rak A, Vall?e F, Michot N, Aug? F, Menet V, Bergis OE, George P, Avenet P, Mikol V, Didier M, Escoubet J. Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents. Sci Rep. 2015 Jan 6;5:7642. doi: 10.1038/srep07642. PubMed PMID: 25560837; PubMed Central PMCID: PMC4284516.