SB-220025 trihydrochloride
| Code | Size | Price |
|---|
| TAR-T24762-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24762-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24762-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
SB-220025 trihydrochloride is an effective and specific human p38 mitogen-activated protein kinase inhibitor.
CAS:
197446-75-6
Formula:
C18H22Cl3FN6
Molecular Weight:
447.76
Purity:
0.98
SMILES:
Cl.Cl.Cl.Nc1nccc(n1)-c1c(ncn1C1CCNCC1)-c1ccc(F)cc1
References
1. Bell CE, Watson AJ. p38 MAPK regulates cavitation and tight junction function in the mouse blastocyst. PLoS One. 2013 Apr 4;8(4):e59528. doi: 10.1371/journal.pone.0059528. Print 2013. PubMed PMID: 23593143; PubMed Central PMCID: PMC3617173.
2. Kanaji N, Nelson A, Allen-Gipson DS, Sato T, Nakanishi M, Wang X, Li Y, Basma H, Michalski J, Farid M, Rennard SI, Liu X. The p38 mitogen-activated protein kinases modulate endothelial cell survival and tissue repair. Inflamm Res. 2012 Mar;61(3):233-44. doi: 10.1007/s00011-011-0405-7. Epub 2011 Dec 3. PubMed PMID: 22138711.
3. Campbell JS, Argast GM, Yuen SY, Hayes B, Fausto N. Inactivation of p38 MAPK during liver regeneration. Int J Biochem Cell Biol. 2011 Feb;43(2):180-8. doi: 10.1016/j.biocel.2010.08.002. Epub 2010 Aug 11. PubMed PMID: 20708092; PubMed Central PMCID: PMC3022113.
4. Sharma A, Guan H, Yang K. The p38 mitogen-activated protein kinase regulates 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) expression in human trophoblast cells through modulation of 11beta-HSD2 messenger ribonucleic acid stability. Endocrinology. 2009 Sep;150(9):4278-86. doi: 10.1210/en.2009-0479. Epub 2009 Jun 4. PubMed PMID: 19497972.