sEH-IN-12
| Code | Size | Price |
|---|
| TAR-T24778-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24778-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24778-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
sEH-IN-12 is an effective inhibitor of the enzyme soluble epoxide hydrolase (sEH).
CAS:
1883803-09-5
Formula:
C25H29N5O2
Molecular Weight:
431.54
Purity:
0.98
SMILES:
CN(CCn1cccn1)C(=O)c1ccc(nc1)-c1cccc(c1)C(=O)NC1CCCCC1
References
1. Chang LH, Lin HC, Huang SS, Chen IC, Chu KW, Chih CL, Liang YW, Lee YC, Chen YY, Lee YH, Lee IH. Blockade of soluble epoxide hydrolase attenuates post-ischemic neuronal hyperexcitation and confers resilience against stroke with TrkB activation. Sci Rep. 2018 Jan 8;8(1):118. doi: 10.1038/s41598-017-18558-6. PubMed PMID: 29311641; PubMed Central PMCID: PMC5758800.
2. Yang SH, Kim YC, An JN, Kim JH, Lee J, Lee HY, Cho JY, Paik JH, Oh YK, Lim CS, Kim YS, Lee JP. Active maintenance of endothelial cells prevents kidney fibrosis. Kidney Res Clin Pract. 2017 Dec;36(4):329-341. doi: 10.23876/j.krcp.2017.36.4.329. Epub 2017 Dec 31. PubMed PMID: 29285425; PubMed Central PMCID: PMC5743042.
3. Hung TH, Shyue SK, Wu CH, Chen CC, Lin CC, Chang CF, Chen SF. Deletion or inhibition of soluble epoxide hydrolase protects against brain damage and reduces microglia-mediated neuroinflammation in traumatic brain injury. Oncotarget. 2017 Sep 21;8(61):103236-103260. doi: 10.18632/oncotarget.21139. eCollection 2017 Nov 28. PubMed PMID: 29262558; PubMed Central PMCID: PMC5732724.
4. Kim HS, Kim SK, Kang KW. Differential Effects of sEH Inhibitors on the Proliferation and Migration of Vascular Smooth Muscle Cells. Int J Mol Sci. 2017 Dec 11;18(12). pii: E2683. doi: 10.3390/ijms18122683. PubMed PMID: 29232926; PubMed Central PMCID: PMC5751285.