TargetMol

SGE-201

Product Code:
 
TAR-T24787
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24787-5mg5mg£850.00
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TAR-T24787-50mg50mg£1,661.00
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Quantity:
TAR-T24787-100mg100mg£2,079.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
SGE-201 is an allosteric modulator of N-methyl-D-aspartate receptors. SGE-201 also unmasked differences among the blockers in neuronal networks - measured either by suppression of activity in multi-electrode arrays or by neuroprotection against a mild excitotoxic insult.
CAS:
35882-85-0
Formula:
C26H44O2
Molecular Weight:
388.636
Purity:
0.98
SMILES:
[H][C@@]12CC[C@H]([C@H](C)CCC(C)(C)O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C

References

1. Emnett CM, Eisenman LN, Mohan J, Taylor AA, Doherty JJ, Paul SM, Zorumski CF, Mennerick S. Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel. Br J Pharmacol. 2015 Mar;172(5):1333-47. doi: 10.1111/bph.13007. Epub 2015 Jan 13. PubMed PMID: 25377730; PubMed Central PMCID: PMC4337705. 2. Paul SM, Doherty JJ, Robichaud AJ, Belfort GM, Chow BY, Hammond RS, Crawford DC, Linsenbardt AJ, Shu HJ, Izumi Y, Mennerick SJ, Zorumski CF. The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. J Neurosci. 2013 Oct 30;33(44):17290-300. doi: 10.1523/JNEUROSCI.2619-13.2013. PubMed PMID: 24174662; PubMed Central PMCID: PMC3812502.