Sparsomycin
| Code | Size | Price |
|---|
| TAR-T24819-5mg | 5mg | £973.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Sparsomycin is an antitumor antibiotic. It also inhibits protein synthesis in the 70S and 80S ribosomal systems.
CAS:
1404-64-4
Formula:
C13H19N3O5S2
Molecular Weight:
361.43
Purity:
0.98
SMILES:
O=C(N[C@@H](CO)CS(CSC)=O)/C=C/C1=C(C)NC(NC1=O)=O
References
1. Miyauchi K, Komano J, Myint L, Futahashi Y, Urano E, Matsuda Z, Chiba T, Miura H, Sugiura W, Yamamoto N. Rapid propagation of low-fitness drug-resistant mutants of human immunodeficiency virus type 1 by a streptococcal metabolite sparsomycin. Antivir Chem Chemother. 2006;17(4):167-74. PubMed PMID: 17066895.
2. Ge X, Roux B. Absolute binding free energy calculations of sparsomycin analogs to the bacterial ribosome. J Phys Chem B. 2010 Jul 29;114(29):9525-39. doi: 10.1021/jp100579y. PubMed PMID: 20608691.
3. Li S, Cheng X, Zhou Y, Xi Z. Sparsomycin-linezolid conjugates can promote ribosomal translocation. Chembiochem. 2011 Dec 16;12(18):2801-6. doi: 10.1002/cbic.201100508. Epub 2011 Oct 28. PubMed PMID: 22038852.
4. Ge X, Roux B. Calculation of the standard binding free energy of sparsomycin to the ribosomal peptidyl-transferase P-site using molecular dynamics simulations with restraining potentials. J Mol Recognit. 2010 Mar-Apr;23(2):128-41. doi: 10.1002/jmr.996. PubMed PMID: 20151411.