tHGA
| Code | Size | Price |
|---|
| TAR-T24877-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24877-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24877-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
tHGA is a potent inhibitor of lipoxygenase.
CAS:
43230-43-9
Formula:
C18H24O4
Molecular Weight:
304.386
Purity:
0.98
SMILES:
CC(C)=CCCC(C)=CCc1c(O)cc(O)c(C(C)=O)c1O
References
1. Lee YZ, Yap HM, Shaari K, Tham CL, Sulaiman MR, Israf DA. Blockade of Eosinophil-Induced Bronchial Epithelial-Mesenchymal Transition with a Geranyl Acetophenone in a Coculture Model. Front Pharmacol. 2017 Nov 16;8:837. doi: 10.3389/fphar.2017.00837. eCollection 2017. PubMed PMID: 29201006; PubMed Central PMCID: PMC5696322.
2. Tan JW, Israf DA, Md Hashim NF, Cheah YK, Harith HH, Shaari K, Tham CL. LAT is essential for the mast cell stabilising effect of tHGA in IgE-mediated mast cell activation. Biochem Pharmacol. 2017 Nov 15;144:132-148. doi: 10.1016/j.bcp.2017.08.010. Epub 2017 Aug 13. PubMed PMID: 28813645.
3. Tan JW, Israf DA, Harith HH, Md Hashim NF, Ng CH, Shaari K, Tham CL. Anti-allergic activity of 2,4,6-trihydroxy-3-geranylacetophenone (tHGA) via attenuation of IgE-mediated mast cell activation and inhibition of passive systemic anaphylaxis. Toxicol Appl Pharmacol. 2017 Mar 15;319:47-58. doi: 10.1016/j.taap.2017.02.002. Epub 2017 Feb 4. PubMed PMID: 28167223.
4. Lee YZ, Shaari K, Cheema MS, Tham CL, Sulaiman MR, Israf DA. An orally active geranyl acetophenone attenuates airway remodeling in a murine model of chronic asthma. Eur J Pharmacol. 2017 Feb 15;797:53-64. doi: 10.1016/j.ejphar.2017.01.011. Epub 2017 Jan 12. PubMed PMID: 28089919.