Tingenin B
| Code | Size | Price |
|---|
| TAR-T24883-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro. Tingenin b was cytotoxic against MCF-7s (IC50: 2.38 μM for 48 h) by inducing apoptosis. Endoplasmic reticulum stress was also found to be involved in tingenin b-induced cell death.
CAS:
50656-68-3
Formula:
C28H36O4
Molecular Weight:
436.592
Purity:
0.98
SMILES:
C[C@@H]1C[C@@H]2[C@@](C)(CC[C@@]3(C)C4=CC=C5C(C)=C(O)C(=O)C=C5[C@@]4(C)CC[C@@]23C)[C@H](O)C1=O
References
1. Cevatemre B, Botta B, Mori M, Berardozzi S, Ingallina C, Ulukaya E. The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro. Chem Biol Interact. 2016 Dec 25;260:248-255. doi: 10.1016/j.cbi.2016.10.001. Epub 2016 Oct 5. PubMed PMID: 27720947.
2. Bavovada R, Blask? G, Shieh HL, Pezzuto JM, Cordell GA. Spectral assignment and cytotoxicity of 22-hydroxytingenone from Glyptopetalum sclerocarpum. Planta Med. 1990 Aug;56(4):380-2. PubMed PMID: 2236293.
3. Maregesi SM, Hermans N, Dhooghe L, Cimanga K, Ferreira D, Pannecouque C, Vanden Berghe DA, Cos P, Maes L, Vlietinck AJ, Apers S, Pieters L. Phytochemical and biological investigations of Elaeodendron schlechteranum. J Ethnopharmacol. 2010 Jun 16;129(3):319-26. doi: 10.1016/j.jep.2010.03.034. Epub 2010 Apr 3. PubMed PMID: 20371284.