Vesamicol
| Code | Size | Price |
|---|
| TAR-T24934-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24934-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24934-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Vesamicol is an experimental drug. It acting presynaptically by inhibiting acetylcholine uptake into synaptic vesicles and reducing its release.
CAS:
22232-64-0
Formula:
C17H25NO
Molecular Weight:
259.393
Purity:
0.98
SMILES:
OC1CCCCC1N1CCC(CC1)c1ccccc1
References
1. Ogawa K, Masuda R, Mizuno Y, Makino A, Kozaka T, Kitamura Y, Kiyono Y, Shiba K, Odani A. Development of a novel radiobromine-labeled sigma-1 receptor imaging probe. Nucl Med Biol. 2018 Apr 6;61:28-35. doi: 10.1016/j.nucmedbio.2018.03.005. [Epub ahead of print] PubMed PMID: 29704822.
2. Lindemann M, Deuther-Conrad W, Moldovan R, Sekhar KVGC, Brust P, Wenzel B. Do spiroindolines have the potential to replace vesamicol as lead compound for the development of radioligands targeting the vesicular acetylcholine transporter? Bioorg Med Chem. 2017 Oct 1;25(19):5107-5113. doi: 10.1016/j.bmc.2017.03.028. Epub 2017 Mar 18. PubMed PMID: 28347632.
3. Sharma A, Agarwal J, Peddinti RK. Direct access to the optically active VAChT inhibitor vesamicol and its analogues via the asymmetric aminolysis of meso-epoxides with secondary aliphatic amines. Org Biomol Chem. 2017 Feb 22;15(8):1913-1920. doi: 10.1039/c6ob02479c. PubMed PMID: 28169381.
4. Gaydukov AE, Bogacheva PO, Balezina OP. Calcitonin gene-related peptide increases acetylcholine quantal size in neuromuscular junctions of mice. Neurosci Lett. 2016 Aug 15;628:17-23. doi: 10.1016/j.neulet.2016.06.014. Epub 2016 Jun 7. PubMed PMID: 27288020.