(-)-Sotalol
| Code | Size | Price |
|---|
| TAR-T24955-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24955-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24955-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
(-)-Sotalol is a non-selective competitive beta-adrenergic receptor blocker that also shows Class III antiarrhythmic properties.
CAS:
30236-31-8
Formula:
C12H20N2O3S
Molecular Weight:
272.36
Purity:
0.98
SMILES:
CC(C)NC[C@H](O)c1ccc(NS(C)(=O)=O)cc1
References
1. Darpo B, Karnad DR, Badilini F, Florian J, Garnett CE, Kothari S, Panicker GK, Sarapa N. Are women more susceptible than men to drug-induced QT prolongation? Concentration-QTc modelling in a phase 1 study with oral rac-sotalol. Br J Clin Pharmacol. 2014 Mar;77(3):522-31. doi: 10.1111/bcp.12201. PubMed PMID: 23819796; PubMed Central PMCID: PMC4371537.
2. Feiner M, Laforsch C, Letzel T, Geist J. Sublethal effects of the beta-blocker sotalol at environmentally relevant concentrations on the New Zealand mudsnail Potamopyrgus antipodarum. Environ Toxicol Chem. 2014 Nov;33(11):2510-5. doi: 10.1002/etc.2699. Epub 2014 Aug 28. PubMed PMID: 25132045.
3. Rivolta MW, Mainardi LT, Sassi R. Quantification of ventricular repolarization heterogeneity during moxifloxacin or sotalol administration using [Formula: see text]-index. Physiol Meas. 2015 Apr;36(4):803-11. doi: 10.1088/0967-3334/36/4/803. Epub 2015 Mar 23. PubMed PMID: 25798997.
4. Somberg JC, Preston RA, Ranade V, Cvetanovic I, Molnar J. Gender differences in cardiac repolarization following intravenous sotalol administration. J Cardiovasc Pharmacol Ther. 2012 Mar;17(1):86-92. doi: 10.1177/1074248411406505. Epub 2011 Apr 28. PubMed PMID: 21527783.