2MeSAMP
| Code | Size | Price |
|---|
| TAR-T24975-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24975-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24975-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
2MeSAMP is a P2Y(12) antagonist that works by inhibiting platelet activation through a P2Y(12)/G(i)-dependent mechanism.
CAS:
81921-45-1
Formula:
C11H14N5Na2O7PS
Molecular Weight:
437.27
Purity:
0.98
SMILES:
[Na+].[Na+].CSc1nc(N)c2ncn(C3OC(COP([O-])([O-])=O)C(O)C3O)c2n1
References
1. Tourdot BE, Conaway S, Niisuke K, Edelstein LC, Bray PF, Holinstat M. Mechanism of race-dependent platelet activation through the protease-activated receptor-4 and Gq signaling axis. Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2644-50. doi: 10.1161/ATVBAHA.114.304249. Epub 2014 Oct 2. PubMed PMID: 25278289; PubMed Central PMCID: PMC4239175.
2. Li R, Diamond SL. Detection of platelet sensitivity to inhibitors of COX-1, P2Y?, and P2Y?? using a whole blood microfluidic flow assay. Thromb Res. 2014 Feb;133(2):203-10. doi: 10.1016/j.thromres.2013.10.043. Epub 2013 Nov 6. PubMed PMID: 24365044; PubMed Central PMCID: PMC3932538.
3. Li??n-Rico A, Wunderlich JE, Grants IS, Frankel WL, Xue J, Williams KC, Harzman AE, Enneking JT, Cooke HJ, Christofi FL. Purinergic autocrine regulation of mechanosensitivity and serotonin release in a human EC model: ATP-gated P2X3 channels in EC are downregulated in ulcerative colitis. Inflamm Bowel Dis. 2013 Oct;19(11):2366-79. doi: 10.1097/MIB.0b013e31829ecf4d. PubMed PMID: 23917247; PubMed Central PMCID: PMC4037929.
4. Herfindal L, Nygaard G, Kopperud R, Krakstad C, D?skeland SO, Selheim F. Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets. Biochem Biophys Res Commun. 2013 Aug 9;437(4):603-8. doi: 10.1016/j.bbrc.2013.07.007. Epub 2013 Jul 12. PubMed PMID: 23850619.