5,11-methenyltetrahydrohomofolate
| Code | Size | Price |
|---|
| TAR-T24980-5mg | 5mg | £1,010.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24980-50mg | 50mg | £1,982.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24980-100mg | 100mg | £2,560.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
5,11-methenyltetrahydrohomofolate is an inhibitor of glycinamide ribonucleotide transformylase and aminoimidazole ribonucleotide transformylase used as an anti-purine drug.
CAS:
118252-44-1
Formula:
C19H24N6O6
Molecular Weight:
432.437
Purity:
0.98
SMILES:
Nc1nc(=O)c(CCCNc2ccc(cc2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c(N)[nH]1
References
1. Denk MK, Milutinovi? NS. Reductive dehalogenation of DDT with folate models: Formation of the DDT metabolite spectrum under biomimetic conditions. Chemosphere. 2018 Jan;191:408-411. doi: 10.1016/j.chemosphere.2017.10.055. Epub 2017 Oct 11. PubMed PMID: 29054081.
2. Gustafsson R, Jemth AS, Gustafsson NM, F?rneg?rdh K, Loseva O, Wiita E, Bonagas N, Dahllund L, Llona-Minguez S, H?ggblad M, Henriksson M, Andersson Y, Homan E, Helleday T, Stenmark P. Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor. Cancer Res. 2017 Feb 15;77(4):937-948. doi: 10.1158/0008-5472.CAN-16-1476. Epub 2016 Nov 29. PubMed PMID: 27899380.
3. Garg D, Skouloubris S, Briffotaux J, Myllykallio H, Wade RC. Conservation and Role of Electrostatics in Thymidylate Synthase. Sci Rep. 2015 Nov 27;5:17356. doi: 10.1038/srep17356. PubMed PMID: 26612036; PubMed Central PMCID: PMC4661567.
4. Nilaweera TD, Saeed M, Kohen A. Targeting the de novo biosynthesis of thymidylate for the development of a PET probe for pancreatic cancer imaging. Biochemistry. 2015 Feb 10;54(5):1287-93. doi: 10.1021/bi501481n. Epub 2015 Jan 27. PubMed PMID: 25581782; PubMed Central PMCID: PMC4324125.