MreB Perturbing Compound A22 hydrochloride
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| TAR-T24994-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| TAR-T24994-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been proved to be an antibiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport.
CAS:
22816-60-0
Formula:
C8H9Cl3N2S
Molecular Weight:
271.58
Purity:
0.98
SMILES:
Cl.NC(=N)SCc1ccc(Cl)c(Cl)c1
References
1. Bonez PC, Rossi GG, Bandeira JR, Ramos AP, Mizdal CR, Agertt VA, Dalla Nora ESS, de Souza ME, Dos Santos Alves CF, Dos Santos FS, G?ndel A, de Almeida Vaucher R, Santos RCV, de Campos MMA. Anti-biofilm activity of A22 ((S-3,4-dichlorobenzyl) isothiourea hydrochloride) against Pseudomonas aeruginosa: Influence on biofilm formation, motility and bioadhesion. Microb Pathog. 2017 Oct;111:6-13. doi: 10.1016/j.micpath.2017.08.008. Epub 2017 Aug 10. PubMed PMID: 28804018.
2. Bonez PC, Ramos AP, Nascimento K, Copetti PM, Souza ME, Rossi GG, Agertt VA, Sagrillo MR, Santos RC, Campos MM. Antibacterial, cyto and genotoxic activities of A22 compound ((S-3, 4 -dichlorobenzyl) isothiourea hydrochloride). Microb Pathog. 2016 Oct;99:14-18. doi: 10.1016/j.micpath.2016.07.007. Epub 2016 Jul 16. PubMed PMID: 27427089.
3. Nicholson A, Perry JD, James AL, Stanforth SP, Carnell S, Wilkinson K, Anjam Khan CM, De Soyza A, Gould FK. In vitro activity of S-(3,4-dichlorobenzyl)isothiourea hydrochloride and novel structurally related compounds against multidrug-resistant bacteria, including Pseudomonas aeruginosa and Burkholderia cepacia complex. Int J Antimicrob Agents. 2012 Jan;39(1):27-32. doi: 10.1016/j.ijantimicag.2011.08.015. Epub 2011 Oct 10. PubMed PMID: 21993484.