Azaline
| Code | Size | Price |
|---|
| TAR-T25129-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Azaline is a gonadorelin antagonist.
CAS:
134457-26-4
Formula:
C74H106ClN23O12
Molecular Weight:
1545.26
Purity:
0.98
SMILES:
CC(C)C[C@H](NC(=O)[C@H](N)CCCCNc1n[nH]c(N)n1)C(=O)N(C(=O)[C@@H](N)CCCCNc1n[nH]c(N)n1)C(=O)[C@@](CC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)(N(C(=O)[C@H](CO)NC(=O)[C@H](N)Cc1cccnc1)C(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCNC(C)C)C(=O)[C@H](N)Cc1ccc(Cl)cc1
References
1. Ballantyne K, Anderson ST, Pyne M, Nicolson V, Mucci A, Lisle A, Johnston SD. Use of the gonadotrophin-releasing hormone antagonist azaline B to control the oestrous cycle in the koala (Phascolarctos cinereus). Reprod Fertil Dev. 2015 May 1. doi: 10.1071/RD14349. [Epub ahead of print] PubMed PMID: 25929179.
2. Chakraborty P, Roy SK. Effect of azaline B on follicular development and functions in the hamster. Mol Cell Endocrinol. 2015 Jan 15;400:1-9. doi: 10.1016/j.mce.2014.11.011. Epub 2014 Nov 24. PubMed PMID: 25462584; PubMed Central PMCID: PMC4274241.
3. Campen CA, Lai MT, Kraft P, Kirchner T, Phillips A, Hahn DW, Rivier J. Potent pituitary-gonadal axis suppression and extremely low anaphylactoid activity of a new gonadotropin releasing hormone (GnRH) receptor antagonist "azaline B". Biochem Pharmacol. 1995 May 11;49(9):1313-21. PubMed PMID: 7763313.
4. Rivier JE, Jiang G, Porter J, Hoeger CA, Craig AG, Corrigan A, Vale W, Rivier CL. Gonadotropin-releasing hormone antagonists: novel members of the azaline B family. J Med Chem. 1995 Jul 7;38(14):2649-62. PubMed PMID: 7629804.