BMS 180742
| Code | Size | Price |
|---|
| TAR-T25164-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
BMS 180742 is an exosite inhibitor of thrombin.
CAS:
138828-04-3
Formula:
C67H93N11O22
Molecular Weight:
1404.536
Purity:
0.98
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](CCC(N)=O)C(O)=O
References
1. Schumacher WA, Steinbacher TE, Heran CL, Seiler SM, Michel IM, Ogletree ML. Comparison of thrombin active site and exosite inhibitors and heparin in experimental models of arterial and venous thrombosis and bleeding. J Pharmacol Exp Ther. 1993 Dec;267(3):1237-42. PubMed PMID: 8263785.
2. Tesfamariam B, Allen GT, Normandin D, Antonaccio MJ. Involvement of the "tethered ligand" receptor in thrombin-induced endothelium-mediated relaxations. Am J Physiol. 1993 Nov;265(5 Pt 2):H1744-9. PubMed PMID: 8238588.
3. Webb ML, Taylor DS, Molloy CJ. Effects of thrombin receptor activating peptide on phosphoinositide hydrolysis and protein kinase C activation in cultured rat aortic smooth muscle cells: evidence for "tethered-ligand" activation of smooth muscle cell thrombin receptors. Biochem Pharmacol. 1993 Apr 22;45(8):1577-82. PubMed PMID: 8387299.
4. Seiler SM, Michel IM, Fenton JW 2nd. Involvement of the "tethered-ligand" receptor in thrombin inhibition of platelet adenylate cyclase. Biochem Biophys Res Commun. 1992 Feb 14;182(3):1296-302. PubMed PMID: 1371679.