CB 3717

TargetMol
Product Code: TAR-T25208
Supplier: TargetMol
CodeSizePrice
TAR-T25208-5mg5mg£930.00
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Quantity:
TAR-T25208-50mg50mg£1,821.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T25208-100mg100mg£2,319.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
CB 3717 is an enzyme inhibitor, antineoplastic agent, folic acid antagonist.
CAS:
76849-19-9
Formula:
C24H23N5O6
Molecular Weight:
477.477
Purity:
0.98
SMILES:
Nc1nc(=O)c2cc(CN(CC#C)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)ccc2[nH]1

References

1. Bayoumi AS, Teoh JP, Aonuma T, Yuan Z, Ruan X, Tang Y, Su H, Weintraub NL, Kim IM. MicroRNA-532 protects the heart in acute myocardial infarction, and represses prss23, a positive regulator of endothelial-to-mesenchymal transition. Cardiovasc Res. 2017 Nov 1;113(13):1603-1614. doi: 10.1093/cvr/cvx132. PubMed PMID: 29016706; PubMed Central PMCID: PMC5852516. 2. Tang Y, Wang Y, Park KM, Hu Q, Teoh JP, Broskova Z, Ranganathan P, Jayakumar C, Li J, Su H, Tang Y, Ramesh G, Kim IM. MicroRNA-150 protects the mouse heart from ischaemic injury by regulating cell death. Cardiovasc Res. 2015 Jun 1;106(3):387-97. doi: 10.1093/cvr/cvv121. Epub 2015 Mar 30. PubMed PMID: 25824147; PubMed Central PMCID: PMC4447807. 3. M?ller C, Reddy JA, Leamon CP, Schibli R. Effects of the antifolates pemetrexed and CB3717 on the tissue distribution of (99m)Tc-EC20 in xenografted and syngeneic tumor-bearing mice. Mol Pharm. 2010 Apr 5;7(2):597-604. doi: 10.1021/mp900296k. PubMed PMID: 20199053. 4. Arvizu-Flores AA, Aispuro-Hernandez E, Garcia-Orozco KD, Varela-Romero A, Valenzuela-Soto E, Velazquez-Contreras EF, Rojo-Dom?nguez A, Yepiz-Plascencia G, Maley F, Sotelo-Mundo RR. Functional identity of the active sites of crustacean and viral thymidylate synthases. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Sep;150(3):406-13. doi: 10.1016/j.cbpc.2009.06.008. Epub 2009 Jun 25. PubMed PMID: 19559812.