CH 66
| Code | Size | Price |
|---|
| TAR-T25233-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
CH 66 is an inhibitor of renin.
CAS:
139890-66-7
Formula:
C58H81N11O12
Molecular Weight:
1124.351
Purity:
0.98
SMILES:
CC(C)CC(NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)C(C)(C)C)C(O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(N)=O
References
1. Dealwis CG, Frazao C, Badasso M, Cooper JB, Tickle IJ, Driessen H, Blundell TL, Murakami K, Miyazaki H, Sueiras-Diaz J, et al. X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen. J Mol Biol. 1994 Feb 11;236(1):342-60. PubMed PMID: 8107115.
2. Kvist S, Mulvany MJ, Aalkjaer C. Studies of the renin-angiotensin system in the wall of rat femoral resistance vessels. Eur J Pharmacol. 1991 May 30;198(1):77-83. PubMed PMID: 1915579.
3. Guruprasad K, Blundell TL, Xie S, Green J, Szafranska B, Nagel RJ, McDowell K, Baker CB, Roberts RM. Comparative modelling and analysis of amino acid substitutions suggests that the family of pregnancy-associated glycoproteins includes both active and inactive aspartic proteinases. Protein Eng. 1996 Oct;9(10):849-56. PubMed PMID: 8931124.
4. Kervinen J, T?rm?kangas K, Runeberg-Roos P, Guruprasad K, Blundell T, Teeri TH. Structure and possible function of aspartic proteinases in barley and other plants. Adv Exp Med Biol. 1995;362:241-54. Review. PubMed PMID: 8540324.