Clorobiocin
| Code | Size | Price |
|---|
| TAR-T25265-5mg | 5mg | £2,776.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Clorobiocin is an aminocoumarin antibacterial that suppresses the enzyme DNA gyrase.
CAS:
39868-96-7
Formula:
C35H37ClN2O11
Molecular Weight:
697.13
Purity:
0.98
SMILES:
CO[C@@H]1[C@@H](OC(=O)c2ccc(C)[nH]2)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2Cl)OC1(C)C
References
1. R?ckert C, Kalinowski J, Heide L, Apel AK. Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin. Genome Announc. 2014 Jan 9;2(1). pii: e01147-13. doi: 10.1128/genomeA.01147-13. PubMed PMID: 24407645; PubMed Central PMCID: PMC3886958.
2. Flinspach K, Westrich L, Kaysser L, Siebenberg S, Gomez-Escribano JP, Bibb M, Gust B, Heide L. Heterologous expression of the biosynthetic gene clusters of coumermycin A(1), clorobiocin and caprazamycins in genetically modified Streptomyces coelicolor strains. Biopolymers. 2010 Sep;93(9):823-32. doi: 10.1002/bip.21493. PubMed PMID: 20578003.
3. Eust?quio AS, Gust B, Luft T, Li SM, Chater KF, Heide L. Clorobiocin biosynthesis in Streptomyces: identification of the halogenase and generation of structural analogs. Chem Biol. 2003 Mar;10(3):279-88. PubMed PMID: 12670542.
4. Freitag A, Wemakor E, Li SM, Heide L. Acyl transfer in clorobiocin biosynthesis: involvement of several proteins in the transfer of the pyrrole-2-carboxyl moiety to the deoxysugar. Chembiochem. 2005 Dec;6(12):2316-25. PubMed PMID: 16276503.