Cucumarioside A2-2
| Code | Size | Price |
|---|
| TAR-T25278-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Cucumarioside A2-2 is a triterpene glycoside isolated from the Far-Eastern sea cucumber Cucumaria japonica, that exhibits antitumor activity.
CAS:
95499-80-2
Formula:
C59H91NaO29S
Molecular Weight:
1319.4
Purity:
0.98
SMILES:
[Na+].COC1C(O)C(CO)OC(OC2C(O)C(CO)OC(OC3C(C)OC(OC4C(O)C(COC4OC4CCC5(C)C6CCC78C(C(=O)CC7(C)C6=CCC5C4(C)C)C(C)(CCCC(C)=C)OC8=O)OS([O-])(=O)=O)C(OC4OCC(O)C(O)C4O)C3O)C2O)C1O
References
1. Menchinskaya ES, Pislyagin EA, Kovalchyk SN, Davydova VN, Silchenko AS, Avilov SA, Kalinin VI, Aminin DL. Antitumor activity of cucumarioside A2-2. Chemotherapy. 2013;59(3):181-91. doi: 10.1159/000354156. Epub 2013 Nov 8. PubMed PMID: 24217558.
2. Pislyagin EA, Dmitrenok PS, Gorpenchenko TY, Avilov SA, Silchenko AS, Aminin DL. Determination of cucumarioside A?-2 in mouse spleen by radiospectroscopy, MALDI-MS and MALDI-IMS. Eur J Pharm Sci. 2013 Jul 16;49(4):461-7. doi: 10.1016/j.ejps.2013.05.017. Epub 2013 May 30. PubMed PMID: 23727465.
3. Menchinskaya ES, Aminin DL, Avilov SA, Silchenko AS, Andryjashchenko PV, Kalinin VI, Stonik VA. Inhibition of tumor cells multidrug resistance by cucumarioside A2-2, frondoside A and their complexes with cholesterol. Nat Prod Commun. 2013 Oct;8(10):1377-80. PubMed PMID: 24354179.
4. Pislyagin EA, Manzhulo IV, Dmitrenok PS, Aminin DL. Cucumarioside A2-2 causes changes in the morphology and proliferative activity in mouse spleen. Acta Histochem. 2016 May;118(4):387-92. doi: 10.1016/j.acthis.2016.03.009. Epub 2016 Apr 11. PubMed PMID: 27079859.