TargetMol

Cytochrome P450 2C9

Product Code:
 
TAR-T25283
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25283-5mg5mg£850.00
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Further Information

Bioactivity:
Cytochrome P450 2C9 is a cytochrome P-450 subtype that possesses specificity for acidic xenobiotics. It oxidizes a wide range of important clinical drugs under the categories of nonsteroidal anti-inflammatory agents, anticoagulants, hypoglycemic agents, and diuretics.
CAS:
329978-01-0
Formula:
C37H40FeN5O7S
Molecular Weight:
754.66
Purity:
0.98
SMILES:
O.[Fe+3].NC(C[S-])C(O)=O.Cc1c(CCC(O)=O)c2cc3[n-]c(cc4nc(cc5[n-]c(cc1n2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(O)=O

References

1. Wang Z, Sun W, Huang CK, Wang L, Xia MM, Cui X, Hu GX, Wang ZS. Inhibitory effects of curcumin on activity of cytochrome P450 2C9 enzyme in human and 2C11 in rat liver microsomes. Drug Dev Ind Pharm. 2015 Apr;41(4):613-6. doi: 10.3109/03639045.2014.886697. Epub 2014 Feb 12. PubMed PMID: 24517573. 2. Wei X, Zhang D, Dou X, Niu N, Huang W, Bai J, Zhang G. Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer. BMC Cancer. 2014 Nov 18;14:841. doi: 10.1186/1471-2407-14-841. PubMed PMID: 25406731; PubMed Central PMCID: PMC4247238. 3. Wang H, Ren L, He Y, Wei Y, Chen Z, Yang W, Fu Y, Xu X, Fu W, Hu G, Lou W. Association between cytochrome P450 2C9 gene polymorphisms and colorectal cancer susceptibility: evidence from 16 case-control studies. Tumour Biol. 2014 May;35(5):4317-22. doi: 10.1007/s13277-013-1566-5. Epub 2014 Jan 11. PubMed PMID: 24414392. 4. Van Booven D, Marsh S, McLeod H, Carrillo MW, Sangkuhl K, Klein TE, Altman RB. Cytochrome P450 2C9-CYP2C9. Pharmacogenet Genomics. 2010 Apr;20(4):277-81. doi: 10.1097/FPC.0b013e3283349e84. Review. PubMed PMID: 20150829; PubMed Central PMCID: PMC3201766.