Ditekiren
| Code | Size | Price |
|---|
| TAR-T25345-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Ditekiren is a renin inhibitor with orally active.
CAS:
103336-05-6
Formula:
C50H75N9O8
Molecular Weight:
930.205
Purity:
0.98
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@@H](C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)OC(C)(C)C)C(C)C)C(=O)NCc1ccccn1
References
1. Zimmerman BG. Greater blood pressure-lowering effect of the renin inhibitor EMD 58265 than an angiotensin-converting enzyme inhibitor in two-kidney one-clip Goldblatt rabbit. Clin Exp Pharmacol Physiol. 2000 May-Jun;27(5-6):370-7. PubMed PMID: 10831238.
2. Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD. Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol Pharmacol. 2000 Jan;57(1):24-35. PubMed PMID: 10617675.
3. Kim RB, Perry PR, Wilkinson GR. High affinity uptake by isolated rat hepatocytes of a linear pseudo-hexapeptide, ditekiren. Biochim Biophys Acta. 1997 Aug 14;1328(1):41-7. PubMed PMID: 9298943.
4. Takahashi H, Kim RB, Perry PR, Wilkinson GR. Characterization of the hepatic canalicular membrane transport of a model oligopeptide: ditekiren. J Pharmacol Exp Ther. 1997 Apr;281(1):297-303. PubMed PMID: 9103510.