HI-236
Code | Size | Price |
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TAR-T25501-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T25501-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T25501-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
HI-236 is used as a non-nucleoside HIV-1 reverse-transcriptase inhibitor.
CAS:
233271-65-3
Formula:
C16H18BrN3O2S
Molecular Weight:
396.3
Purity:
0.98
SMILES:
COc1ccc(OC)c(CCNC(=S)Nc2ccc(Br)cn2)c1
References
1. Younis Y, Hunter R, Muhanji CI, Hale I, Singh R, Bailey CM, Sullivan TJ, Anderson KS. [d4U]-spacer-[HI-236] double-drug inhibitors of HIV-1 reverse-transcriptase. Bioorg Med Chem. 2010 Jul 1;18(13):4661-73. doi: 10.1016/j.bmc.2010.05.025. Epub 2010 May 11. PubMed PMID: 20605472; PubMed Central PMCID: PMC2964380.
2. Hunter R, Younis Y, Muhanji CI, Curtin TL, Naidoo KJ, Petersen M, Bailey CM, Basavapathruni A, Anderson KS. C-2-aryl O-substituted HI-236 derivatives as non-nucleoside HIV-1 reverse-transcriptase inhibitors. Bioorg Med Chem. 2008 Dec 15;16(24):10270-80. doi: 10.1016/j.bmc.2008.10.048. Epub 2008 Nov 1. PubMed PMID: 18996020; PubMed Central PMCID: PMC2639753.
3. Hunter R, Muhanji CI, Hale I, Bailey CM, Basavapathruni A, Anderson KS. [d4U]-butyne-[HI-236] as a non-cleavable, bifunctional NRTI/NNRTI HIV-1 reverse-transcriptase inhibitor. Bioorg Med Chem Lett. 2007 May 1;17(9):2614-7. Epub 2007 Feb 4. PubMed PMID: 17317163.
4. Mao C, Sudbeck EA, Venkatachalam TK, Uckun FM. Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1593-8. PubMed PMID: 10386942.