ICI 198583
| Code | Size | Price |
|---|
| TAR-T25519-5mg | 5mg | £930.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25519-50mg | 50mg | £1,821.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25519-100mg | 100mg | £2,319.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
ICI 198583 is an inhibitor of antifolate thymidylate synthase.
CAS:
112887-62-4
Formula:
C25H24N4O6
Molecular Weight:
476.489
Purity:
0.98
SMILES:
Cc1nc(=O)c2cc(CN(CC#C)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)ccc2[nH]1
References
1. Chen JH, Zhang N, Wang YQ, Wang JZ, Ji SX, Dang WJ, Li SM, Feng L. Estrogenic effects of flavonoid components in Xiaoyao powder. Genet Mol Res. 2016 Feb 11;15(1). doi: 10.4238/gmr.15017500. PubMed PMID: 26909969.
2. Pawe?czak K, Makowski M, Kempny M, Dzik JM, Go?os B, Rode W, Rzeszotarska B. Sulfamide antifolates inhibiting thymidylate synthase: synthesis, enzyme inhibition and cytotoxicity. Acta Biochim Pol. 2002;49(2):407-20. PubMed PMID: 12362982.
3. Kusakiewicz-Dawid A, Bugaj M, Dzik JM, Go?os B, Wi?ska P, Pawe?czak K, Rzeszotarska B, Rode W. Synthesis and biological activity of N(alpha)-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-propargylami no]phenylacetyl]-L-glutamic acid. Acta Biochim Pol. 2002;49(1):197-203. PubMed PMID: 12136941.
4. Skelton LA, Ormerod MG, Titley JC, Jackman AL. Cell cycle effects of CB30865, a lipophilic quinazoline-based analogue of the antifolate thymidylate synthase inhibitor ICI 198583 with an undefined mechanism of action. Cytometry. 1998 Sep 1;33(1):56-66. PubMed PMID: 9725559.