Kijanimicin
| Code | Size | Price |
|---|
| TAR-T25579-5mg | 5mg | £3,111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Kijanimicin is an antitumor and antibiotic. It is a unique, large acid enol antibiotic and possesses an unusual in vitro spectrum of activity against some Gram-positive and anaerobic microorganisms. It has also shown interesting activity against malaria in vivo.
CAS:
78798-08-0
Formula:
C67H100N2O24
Molecular Weight:
1317.527
Purity:
0.98
SMILES:
CO[C@@H]1[C@H](O)C[C@@H](O[C@H]2[C@H](C)O[C@H](C[C@H]2O[C@H]2C[C@@H](O)[C@@H](O)[C@H](C)O2)O[C@@H]2C[C@H](O[C@H]3[C@@H](C)C[C@H](C)[C@@H]4[C@@H]3C=C[C@H]3C(C)=C/C[C@H](O[C@H]5C[C@@](C)([C@@H](NC(=O)OC)[C@@H](C)O5)[N+]([O-])=O)C(C)=C[C@@H]5C=C(CO)[C@H](C)CC55OC(=O)C(=C5O)C(=O)[C@@]43C)O[C@@H](C)[C@@H]2O)O[C@H]1C
References
1. Bradner WT, Claridge CA, Huftalen JB. Antitumor activity of kijanimicin. J Antibiot (Tokyo). 1983 Aug;36(8):1078-9. PubMed PMID: 6630059.
2. Waitz JA, Horan AC, Kalyanpur M, Lee BK, Loebenberg D, Marquez JA, Miller G, Patel MG. Kijanimicin (Sch 25663), a novel antibiotic produced by Actinomadura kijaniata SCC 1256. Fermentation, isolation, characterization and biological properties. J Antibiot (Tokyo). 1981 Sep;34(9):1101-6. PubMed PMID: 7328052.
3. Zhang H, White-Phillip JA, Melan?on CE 3rd, Kwon HJ, Yu WL, Liu HW. Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars. J Am Chem Soc. 2007 Nov 28;129(47):14670-83. Epub 2007 Nov 7. PubMed PMID: 17985890; PubMed Central PMCID: PMC2515274.
4. Cuthbertson L, Ahn SK, Nodwell JR. Deglycosylation as a mechanism of inducible antibiotic resistance revealed using a global relational tree for one-component regulators. Chem Biol. 2013 Feb 21;20(2):232-40. doi: 10.1016/j.chembiol.2012.11.011. PubMed PMID: 23438752.