KNT-127
| Code | Size | Price |
|---|
| TAR-T25583-5mg | 5mg | £1,026.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25583-50mg | 50mg | £2,464.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25583-100mg | 100mg | £3,283.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
KNT-127 is an agonist of δ-Opioid receptor.
CAS:
1256921-89-7
Formula:
C24H24N2O2
Molecular Weight:
372.468
Purity:
0.98
SMILES:
[H][C@]12Cc3ccc(O)cc3[C@@]3(CCN1C)Cc1nc4ccccc4cc1C[C@@]23O
References
1. Saitoh A, Tominaga H, Ogawa Y, Irukayama-Tomobe Y, Yamada M, Yanagisawa M, Nagase H. Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice. Pharmacol Rep. 2018 Apr;70(2):350-354. doi: 10.1016/j.pharep.2017.08.018. Epub 2017 Oct 28. PubMed PMID: 29477045.
2. Saitoh A, Suzuki S, Soda A, Ohashi M, Yamada M, Oka JI, Nagase H, Yamada M. The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice. Behav Brain Res. 2018 Jan 15;336:77-84. doi: 10.1016/j.bbr.2017.08.041. Epub 2017 Aug 31. PubMed PMID: 28864205.
3. Gotoh L, Saitoh A, Yamada M, Fujii H, Nagase H, Yamada M. Effects of repeated treatment with a delta opioid receptor agonist KNT-127 on hyperemotionality in olfactory-bulbectomized rats. Behav Brain Res. 2017 Apr 14;323:11-14. doi: 10.1016/j.bbr.2016.11.008. Epub 2016 Dec 1. PubMed PMID: 27916688.
4. Saitoh A, Nagase H. Delta Opioid Receptor (DOR) Ligands and Pharmacology: Development of Indolo- and Quinolinomorphinan Derivatives Based on the Message-Address Concept. Handb Exp Pharmacol. 2016 Oct 28. doi: 10.1007/164_2016_18. [Epub ahead of print] PubMed PMID: 27787711.