Lankacidins
| Code | Size | Price |
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| TAR-T25622-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Lankacidins is an antitumor antibiotic of the macrolide tetraenes family from Streptomyces.
CAS:
23623-31-6
Formula:
C25H33NO7
Molecular Weight:
459.539
Purity:
0.98
SMILES:
[H][C@]12C[C@H](O)C=C/C(/C)=CC[C@H](O)C=C/C(/C)=C[C@@H](NC(=O)C(C)=O)[C@](C)(C(=O)O1)C(=O)[C@@H]2C
References
1. He HY, Yuan H, Tang MC, Tang GL. An unusual dehydratase acting on glycerate and a ketoreducatse stereoselectively reducing ?-ketone in polyketide starter unit biosynthesis. Angew Chem Int Ed Engl. 2014 Oct 13;53(42):11315-9. doi: 10.1002/anie.201406602. Epub 2014 Aug 27. PubMed PMID: 25160004.
2. Cao Z, Yoshida R, Kinashi H, Arakawa K. Blockage of the early step of lankacidin biosynthesis caused a large production of pentamycin, citreodiol and epi-citreodiol in Streptomyces rochei. J Antibiot (Tokyo). 2015 May;68(5):328-33. doi: 10.1038/ja.2014.160. Epub 2014 Dec 3. PubMed PMID: 25464973.
3. Ayoub AT, Abou El-Magd RM, Xiao J, Lewis CW, Tilli TM, Arakawa K, Nindita Y, Chan G, Sun L, Glover M, Klobukowski M, Tuszynski J. Antitumor Activity of Lankacidin Group Antibiotics Is Due to Microtubule Stabilization via a Paclitaxel-like Mechanism. J Med Chem. 2016 Oct 27;59(20):9532-9540. Epub 2016 Oct 18. PubMed PMID: 27718573.
4. Arakawa K. Genetic and biochemical analysis of the antibiotic biosynthetic gene clusters on the Streptomyces linear plasmid. Biosci Biotechnol Biochem. 2014;78(2):183-9. doi: 10.1080/09168451.2014.882761. Epub 2014 Apr 16. Review. PubMed PMID: 25036669.