Lankamycin
| Code | Size | Price |
|---|
| TAR-T25624-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Lankamycin is a macrolide antibiotic from various strains of Streptomyces. It may have significant activity against some Gram positive bacteria.
CAS:
30042-37-6
Formula:
C42H72O16
Molecular Weight:
833.022
Purity:
0.98
SMILES:
CO[C@H]1C[C@@H](C)O[C@@H](O[C@H]2[C@@H](C)C[C@](C)(O)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@H](OC(=O)[C@H](C)[C@@H](O[C@H]3C[C@@](C)(OC)[C@H](OC(C)=O)[C@H](C)O3)[C@@H]2C)[C@@H](C)[C@H](C)O)[C@@H]1O
References
1. Belousoff MJ, Shapira T, Bashan A, Zimmerman E, Rozenberg H, Arakawa K, Kinashi H, Yonath A. Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2717-22. doi: 10.1073/pnas.1019406108. Epub 2011 Jan 31. PubMed PMID: 21282615; PubMed Central PMCID: PMC3041097.
2. Arakawa K, Tsuda N, Taniguchi A, Kinashi H. The butenolide signaling molecules SRB1 and SRB2 induce lankacidin and lankamycin production in Streptomyces rochei. Chembiochem. 2012 Jul 9;13(10):1447-57. doi: 10.1002/cbic.201200149. Epub 2012 Jun 14. PubMed PMID: 22761035.
3. Arakawa K. Genetic and biochemical analysis of the antibiotic biosynthetic gene clusters on the Streptomyces linear plasmid. Biosci Biotechnol Biochem. 2014;78(2):183-9. doi: 10.1080/09168451.2014.882761. Epub 2014 Apr 16. Review. PubMed PMID: 25036669.
4. Suzuki T, Mochizuki S, Yamamoto S, Arakawa K, Kinashi H. Regulation of lankamycin biosynthesis in Streptomyces rochei by two SARP genes, srrY and srrZ. Biosci Biotechnol Biochem. 2010;74(4):819-27. Epub 2010 Apr 7. PubMed PMID: 20378964.