Larotaxel dihydrate
| Code | Size | Price |
|---|
| TAR-T25631-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Larotaxel dihydrate possesses antineoplastic activity.
CAS:
192573-38-9
Formula:
C45H57NO16
Molecular Weight:
867.942
Purity:
0.98
SMILES:
O.O.CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@H]3[C@]4(C[C@H]4C[C@H]4OC[C@@]34OC(C)=O)C1=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c1ccccc1
References
1. Sternberg CN, Skoneczna IA, Castellano D, Theodore C, Blais N, Voog E, Bellmunt J, Peters F, Le-Guennec S, Cerbone L, Risse ML, Machiels JP. Larotaxel with Cisplatin in the first-line treatment of locally advanced/metastatic urothelial tract or bladder cancer: a randomized, active-controlled, phase III trial (CILAB). Oncology. 2013;85(4):208-15. doi: 10.1159/000354085. Epub 2013 Sep 24. PubMed PMID: 24080920.
2. Liu Z, Feng Y, Zhang L, Li G, Geng L, Cui Y, Teng F, Tang X, Bi K, Chen X. Pharmacokinetics and tissue distribution of larotaxel in rats: comparison of larotaxel-loaded microsphere with larotaxel-solution. Cancer Chemother Pharmacol. 2013 May;71(5):1131-9. doi: 10.1007/s00280-013-2104-2. Epub 2013 Feb 15. PubMed PMID: 23412629.
3. Teng F, Yang H, Li G, Lin X, Zhang Y, Tang X. Parenteral formulation of larotaxel lipid microsphere tackling poor solubility and chemical instability. Int J Pharm. 2014 Jan 2;460(1-2):212-9. doi: 10.1016/j.ijpharm.2013.10.039. Epub 2013 Oct 29. PubMed PMID: 24184034.
4. Liu Z, Zhang L, Ju P, Hou P, Zhang Y, Tang X, Bi K, Chen X. Determination of larotaxel and its metabolites in rat plasma by liquid chromatography-tandem mass spectrometry: application for a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Feb 1;947-948:132-8. doi: 10.1016/j.jchromb.2013.12.029. Epub 2013 Dec 31. PubMed PMID: 24413022.