Leucinal
| Code | Size | Price |
|---|
| TAR-T25675-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25675-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25675-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Leucinal inhibits the activity of brain aminopeptidase and potentiates analgesia induced by leu-enkephalen.
CAS:
82473-52-7
Formula:
C6H13NO
Molecular Weight:
115.176
Purity:
0.98
SMILES:
CC(C)C[C@H](N)C=O
References
1. Davis KR, Hernandez DE, Wolfenden R. Leucinal inhibits brain aminopeptidase activity and potentiates analgesia induced by leu-enkephalen. Pharmacol Biochem Behav. 1983 Nov;19(5):791-4. PubMed PMID: 6647514.
2. Str?ter N, Lipscomb WN. Two-metal ion mechanism of bovine lens leucine aminopeptidase: active site solvent structure and binding mode of L-leucinal, a gem-diolate transition state analogue, by X-ray crystallography. Biochemistry. 1995 Nov 14;34(45):14792-800. PubMed PMID: 7578088.
3. Princiotta MF, Schubert U, Chen W, Bennink JR, Myung J, Crews CM, Yewdell JW. Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival. Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):513-8. Epub 2001 Jan 9. PubMed PMID: 11149939; PubMed Central PMCID: PMC14618.
4. Ito H, Watanabe M, Kim YT, Takahashi K. Inhibition of rat liver cathepsins B and L by the peptide aldehyde benzyloxycarbonyl-leucyl-leucyl-leucinal and its analogues. J Enzyme Inhib Med Chem. 2009 Feb;24(1):279-86. doi: 10.1080/14756360802166921 . PubMed PMID: 18830882.