Lysobactin
| Code | Size | Price |
|---|
| TAR-T25767-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Lysobactin, also known as katanosin B, is an effective antibiotic with in vivo efficacy against Staphylococcus aureus and Streptococcus pneumoniae. It was previously shown to inhibit peptidoglycan (PG) biosynthesis.
CAS:
118374-47-3
Formula:
C58H97N15O17
Molecular Weight:
1276.502
Purity:
0.98
SMILES:
CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](N)CC(C)C)[C@H](OC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC1=O)[C@H](C)O)[C@H](O)C(N)=O)c1ccccc1)[C@H](O)C(C)C
References
1. Lee W, Schaefer K, Qiao Y, Srisuknimit V, Steinmetz H, M?ller R, Kahne D, Walker S. The Mechanism of Action of Lysobactin. J Am Chem Soc. 2016 Jan 13;138(1):100-3. doi: 10.1021/jacs.5b11807. Epub 2015 Dec 24. PubMed PMID: 26683668; PubMed Central PMCID: PMC4817722.
2. Hou J, Robbel L, Marahiel MA. Identification and characterization of the lysobactin biosynthetic gene cluster reveals mechanistic insights into an unusual termination module architecture. Chem Biol. 2011 May 27;18(5):655-64. doi: 10.1016/j.chembiol.2011.02.012. PubMed PMID: 21609846.
3. Hall EA, Kuru E, VanNieuwenhze MS. Solid-phase synthesis of lysobactin (katanosin B): insights into structure and function. Org Lett. 2012 Jun 1;14(11):2730-3. doi: 10.1021/ol300926d. Epub 2012 May 21. PubMed PMID: 22612400; PubMed Central PMCID: PMC3488444.
4. Blackburn RK, Van Breemen RB. Application of an immobilized digestive enzyme assay to measure chemical and enzymatic hydrolysis of the cyclic peptide antibiotic lysobactin. Drug Metab Dispos. 1993 Jul-Aug;21(4):573-9. PubMed PMID: 8104115.