MAL3-101
| Code | Size | Price |
|---|
| TAR-T25771-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
MAL3-101 is a molecular chaperone inhibitor of heat shock protein 70 (Hsp 70).
CAS:
831217-40-4
Formula:
C54H66N4O10
Molecular Weight:
931.14
Purity:
0.98
SMILES:
CCCCCCN(C(C(=O)NCCCC)c1ccc(OCC(=O)OC)c(c1)C(=O)OC)C(=O)CCCCCN1C(=O)NC(C(C(=O)OCc2ccccc2)=C1C)c1ccc(cc1)-c1ccccc1
References
1. Xing B, Wang L, Li Q, Cao Y, Dong X, Liang J, Wu X. Hsp70 plays an important role in high-fat diet induced gestational hyperglycemia in mice. J Physiol Biochem. 2015 Dec;71(4):649-58. doi: 10.1007/s13105-015-0430-z. Epub 2015 Aug 29. PubMed PMID: 26318018.
2. Adam C, Baeurle A, Brodsky JL, Wipf P, Schrama D, Becker JC, Houben R. The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma. PLoS One. 2014 Apr 2;9(4):e92041. doi: 10.1371/journal.pone.0092041. eCollection 2014. PubMed PMID: 24694787; PubMed Central PMCID: PMC3973671.
3. Kilpatrick K, Novoa JA, Hancock T, Guerriero CJ, Wipf P, Brodsky JL, Segatori L. Chemical induction of Hsp70 reduces ?-synuclein aggregation in neuroglioma cells. ACS Chem Biol. 2013 Jul 19;8(7):1460-8. doi: 10.1021/cb400017h. Epub 2013 May 1. PubMed PMID: 23594135; PubMed Central PMCID: PMC4532326.
4. Fang S, Crews AL, Chen W, Park J, Yin Q, Ren XR, Adler KB. MARCKS and HSP70 interactions regulate mucin secretion by human airway epithelial cells in vitro. Am J Physiol Lung Cell Mol Physiol. 2013 Apr 15;304(8):L511-8. doi: 10.1152/ajplung.00337.2012. Epub 2013 Feb 1. PubMed PMID: 23377348; PubMed Central PMCID: PMC3625989.