Methyl Streptonigrin
| Code | Size | Price |
|---|
| TAR-T25798-5mg | 5mg | £2,295.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25798-50mg | 50mg | £4,552.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25798-100mg | 100mg | £6,416.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Methyl Streptonigrin is an ABCG2 transporter function inhibitor.
CAS:
3398-48-9
Formula:
C26H24N4O8
Molecular Weight:
520.498
Purity:
0.98
SMILES:
COC(=O)c1nc(c(N)c(c1C)-c1ccc(OC)c(OC)c1O)-c1ccc2C(=O)C(OC)=C(N)C(=O)c2n1
References
1. Qian T, Wo J, Zhang Y, Song Q, Feng G, Luo R, Lin S, Wu G, Chen HF. Crystal Structure of StnA for the Biosynthesis of Antitumor Drug Streptonigrin Reveals a Unique Substrate Binding Mode. Sci Rep. 2017 Jan 11;7:40254. doi: 10.1038/srep40254. PubMed PMID: 28074848; PubMed Central PMCID: PMC5225493.
2. Kong D, Zou Y, Zhang Z, Xu F, Brock NL, Zhang L, Deng Z, Lin S. Identification of (2S,3S)-?-Methyltryptophan as the Real Biosynthetic Intermediate of Antitumor Agent Streptonigrin. Sci Rep. 2016 Feb 5;6:20273. doi: 10.1038/srep20273. PubMed PMID: 26847951; PubMed Central PMCID: PMC4742848.
3. Xia X, Lin S, Xia XX, Cong FS, Zhong JJ. Significance of agitation-induced shear stress on mycelium morphology and lavendamycin production by engineered Streptomyces flocculus. Appl Microbiol Biotechnol. 2014 May;98(10):4399-407. doi: 10.1007/s00253-014-5555-4. Epub 2014 Feb 13. PubMed PMID: 24522728.
4. Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S. Characterization of streptonigrin biosynthesis reveals a cryptic carboxyl methylation and an unusual oxidative cleavage of a N-C bond. J Am Chem Soc. 2013 Feb 6;135(5):1739-48. doi: 10.1021/ja3069243. Epub 2013 Jan 22. PubMed PMID: 23301954.