MI 1544
| Code | Size | Price |
|---|
| TAR-T25808-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
MI 1544 is a LHRH antagonist.
CAS:
87565-51-3
Formula:
C71H94ClN17O13
Molecular Weight:
1429.09
Purity:
0.98
SMILES:
CC(C)C[C@H](NC(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](N)Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(C)=O
References
1. Vincze B, P?lyi I, Daubner D, K?lnay A, Mez? G, Hudecz F, Szekerke M, Tepl?n I, Mez? I. Antitumour effect of a gonadotropin-releasing-hormone antagonist (MI-1544) and its conjugate on human breast cancer cells and their xenografts. J Cancer Res Clin Oncol. 1994;120(10):578-84. PubMed PMID: 7929528.
2. Mez? G, Mez? I, Pimm MV, Kajt?r J, Sepr?di J, Tepl?n I, Kov?cs M, Vincze B, P?lyi I, Idei M, Szekerke M, Hudecz F. Synthesis, conformation, biodistribution, and hormone-related in vitro antitumor activity of a gonadotropin-releasing hormone antagonist-branched polypeptide conjugate. Bioconjug Chem. 1996 Nov-Dec;7(6):642-50. PubMed PMID: 8950483.
3. Kov?cs M, Kopp?n M, Mez? I, Tepl?n I, Flerk? B. Antiovulatory doses of antagonists of LH-RH inhibit LH and progesterone but not FSH and estradiol release. J Neuroendocrinol. 1993 Dec;5(6):603-8. PubMed PMID: 8680431.
4. P?lyi I, Vincze B, Lovas S, Mez? I, Pat? J, K?lnay A, Turi G, Ga?l D, Mihalik R, P?ter I, Tepl?n I, Murphy RF. Gonadotropin-releasing hormone analogue conjugates with strong selective antitumor activity. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2361-6. PubMed PMID: 10051647; PubMed Central PMCID: PMC26789.