Mirincamycin HCl
| Code | Size | Price |
|---|
| TAR-T25815-5mg | 5mg | £1,091.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25815-50mg | 50mg | £2,143.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25815-100mg | 100mg | £2,801.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Mirincamycin HCl is a close analog of the drug clindamycin used for the treatment of Plasmodium falciparum blood stages.
CAS:
8063-91-0
Formula:
C19H37Cl3N2O5S
Molecular Weight:
511.92
Purity:
0.98
SMILES:
Cl.Cl.CCCCCC1CN[C@@H](C1)C(=O)N[C@@H]([C@@H](C)Cl)[C@H]1O[C@H](SC)[C@H](O)[C@@H](O)[C@H]1O
References
1. Fracisco S, Teja-isavadharm P, Gettayacamin M, Berman J, Li Q, Melendez V, Saunders D, Xie L, Ohrt C. Anti-relapse activity of mirincamycin in the Plasmodium cynomolgi sporozoite-infected Rhesus monkey model. Malar J. 2014 Oct 17;13:409. doi: 10.1186/1475-2875-13-409. PubMed PMID: 25326032; PubMed Central PMCID: PMC4209072.
2. Khemawoot P, Saunders D, Rasameesoraj M, Melendez V, Imerbsin R, Ohrt C, Fracisco S, Teja-Isavadharm P. Absolute bioavailability of cis-mirincamycin and trans-mirincamycin in healthy rhesus monkeys and ex vivo antimalarial activity against Plasmodium falciparum. Antimicrob Agents Chemother. 2011 Dec;55(12):5881-6. doi: 10.1128/AAC.01619-10. Epub 2011 Sep 26. PubMed PMID: 21947400; PubMed Central PMCID: PMC3232806.
3. Starzengruber P, Fuehrer HP, Swoboda P, Ganesh D, Haque R, Khan WA, Graninger W, Noedl H. Mirincamycin, an old candidate for malaria combination treatment and prophylaxis in the 21st century: in vitro interaction profiles with potential partner drugs in continuous culture and field isolates. Malar J. 2014 Jun 10;13:228. doi: 10.1186/1475-2875-13-228. PubMed PMID: 24916383; PubMed Central PMCID: PMC4059879.
4. Schmidt LH. Enhancement of the curative activity of primaquine by concomitant administration of mirincamycin. Antimicrob Agents Chemother. 1985 Feb;27(2):151-7. PubMed PMID: 3885847; PubMed Central PMCID: PMC176228.