Cilastatin sodium
| Code | Size | Price |
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| TAR-T2583L-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| TAR-T2583L-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Cilastatin is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor.
CAS:
81129-83-1
Formula:
C16H25N2NaO5S
Molecular Weight:
380.43
Purity:
0.98
SMILES:
[Na+].CC1(C)CC1C(=O)NC(=C/CCCCSCC(N)C([O-])=O)C(O)=O
References
1. Chen CH, Lin CH, Lin JS. Bacteremia caused by Elizabethkingia meningoseptica in a mechanically ventilated patient successfully treated with imipenem-cilastatin and ciprofloxacin. Rev Inst Med Trop Sao Paulo. 2017 Jun 1;59:e26. doi: 10.1590/S1678-9946201759026. PubMed PMID: 28591254; PubMed Central PMCID: PMC5459533.
2. Sims M, Mariyanovski V, McLeroth P, Akers W, Lee YC, Brown ML, Du J, Pedley A, Kartsonis NA, Paschke A. Prospective, randomized, double-blind, Phase 2 dose-ranging study comparing efficacy and safety of imipenem/cilastatin plus relebactam with imipenem/cilastatin alone in patients with complicated urinary tract infections. J Antimicrob Chemother. 2017 Jun 1. doi: 10.1093/jac/dkx139. [Epub ahead of print] PubMed PMID: 28575389.
3. Im DS, Shin HJ, Yang KJ, Jung SY, Song HY, Hwang HS, Gil HW. Cilastatin attenuates vancomycin-induced nephrotoxicity via P-glycoprotein. Toxicol Lett. 2017 May 23;277:9-17. doi: 10.1016/j.toxlet.2017.05.023. [Epub ahead of print] PubMed PMID: 28549670.
4. Shaaban MI, Shaker MA, Mady FM. Imipenem/cilastatin encapsulated polymeric nanoparticles for destroying carbapenem-resistant bacterial isolates. J Nanobiotechnology. 2017 Apr 11;15(1):29. doi: 10.1186/s12951-017-0262-9. PubMed PMID: 28399890; PubMed Central PMCID: PMC5387208.