NTE-122
| Code | Size | Price |
|---|
| TAR-T25891-5mg | 5mg | £1,091.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25891-50mg | 50mg | £2,143.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25891-100mg | 100mg | £2,801.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
NTE-122 is a competitive Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
CAS:
166967-84-6
Formula:
C38H58N6O2
Molecular Weight:
630.922
Purity:
0.98
SMILES:
CN(C)c1ccc(NC(=O)N(C[C@H]2CC[C@H](CN(C3CCCCC3)C(=O)Nc3ccc(cc3)N(C)C)CC2)C2CCCCC2)cc1
References
1. Azuma Y, Date K, Ohno K, Matsushiro S, Nobuhara Y, Yamada T. NTE-122, an acyl-coa:cholesterol acyltransferase inhibitor, prevents the progression of atherogenesis in cholesterol-fed rabbits. Jpn J Pharmacol. 2001 May;86(1):120-3. PubMed PMID: 11430463.
2. Ohgami N, Kuniyasu A, Furukawa K, Miyazaki A, Hakamata H, Horiuchi S, Nakayama H. Glibenclamide acts as an inhibitor of acyl-CoA:cholesterol acyltransferase enzyme. Biochem Biophys Res Commun. 2000 Oct 22;277(2):417-22. PubMed PMID: 11032738.
3. Nakayama H, Ohgami N, Kuniyasu A, Miyazaki A, Hakamata H, Horiuchi S. [Glibenclamide inhibits cholesterol metabolism in macrophage]. Nihon Yakurigaku Zasshi. 1999 Oct;114 Suppl 1:150P-153P. Japanese. PubMed PMID: 10629872.
4. Azuma Y, Seto J, Ohno K, Mikami H, Yamada T, Yamasaki M, Chiba M, Nobuhara Y. Effects of NTE-122, an acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and lipid secretion from CaCo-2 cells, and cholesterol absorption in rats. Jpn J Pharmacol. 1999 May;80(1):81-4. PubMed PMID: 10446760.