Org 30850
| Code | Size | Price |
|---|
| TAR-T25901-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Org 30850 is a gonadorelin antagonist.
CAS:
136208-71-4
Formula:
C69H91Cl2N15O13S
Molecular Weight:
1441.54
Purity:
0.98
SMILES:
CC(C)C[C@H](NC(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O
References
1. Deckers GH, de Graaf JH, Kloosterboer HJ, Loozen HJ. Properties of a potent LHRH antagonist (Org 30850) in female and male rats. J Steroid Biochem Mol Biol. 1992 Aug;42(7):705-12. PubMed PMID: 1504009.
2. Franchimont P, Almer SM, Charlet-Renard CJ, Daubresse CL, Kicovic PP. Effects of a novel gonadotropin-releasing hormone antagonist (ORG 30850) on gonadotropin and prolactin secretion by rat pituitary cells in culture. Acta Endocrinol (Copenh). 1991 Jan;124(1):98-106. PubMed PMID: 1900380.
3. Gordon K, Scott RT, Williams RF, Danforth DR, Loozen HJ, Kloosterboer HJ, Hodgen GD. In vivo effects of a potent GnRH antagonist ORG 30850: physiologic evidence that down-regulation of GnRH receptors does not occur. J Soc Gynecol Investig. 1994 Oct-Dec;1(4):290-6. PubMed PMID: 9419786.
4. Hakola K, Boogaart PV, Mulders J, de Leeuw R, Schoonen W, Heyst JV, Swolfs A, Casteren JV, Huhtaniemi I, Kloosterboer H. Recombinant rat luteinizing hormone; production by Chinese hamster ovary cells, purification and functional characterization. Mol Cell Endocrinol. 1997 Apr 4;128(1-2):47-56. PubMed PMID: 9140075.