PD 145065
| Code | Size | Price |
|---|
| TAR-T25923-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
PD 145065 is a non-selective antagonist of endothelin(A)/endothelin(B).
CAS:
153049-49-1
Formula:
C52H67N7O10
Molecular Weight:
950.147
Purity:
0.98
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc12)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
References
1. Wellings RP, Warner TD, Thiemermann C, Cristol JP, Corder R, Vane JR. Vasoconstriction in the rat kidney induced by endothelin-1 is blocked by PD 145065. J Cardiovasc Pharmacol. 1993;22 Suppl 8:S103-6. PubMed PMID: 7509915.
2. Dobrowolski L, Endlich K, Sadowski J, Steinhausen M. Cardiovascular and renal effects of endothelin receptor blockade with PD 145065 and interaction with urodilatin. Acta Physiol Scand. 1997 Jan;159(1):7-13. PubMed PMID: 9124073.
3. Norota I, Endoh M. Pharmacological characteristics of endothelin receptors in the rabbit ventricular myocardium: the nonselective endothelin receptor antagonist PD 145065 antagonizes the positive inotropic effect of endothelin-3 but not of endothelin-1. Mol Cell Biochem. 1996 Jul-Aug;160-161:67-74. PubMed PMID: 8901457.
4. Wellings RP, Corder R, Doherty AM, Vane JR. Antagonism of renal and systemic responses to endothelin-1 infusion with PD 145065. Eur J Pharmacol. 1994 Apr 21;256(2):201-4. PubMed PMID: 8050471.