Phebestin
| Code | Size | Price |
|---|
| TAR-T25940-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Phebestin is an aminopeptidase N inhibitor, produced by Streptomyces sp. MJ716-m3.
CAS:
187402-73-9
Formula:
C24H31N3O5
Molecular Weight:
441.528
Purity:
0.98
SMILES:
CC(C)[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
References
1. Garg PK, Garg S, Degraff WG, Zalutsky MR, Mitchell JB. 4-Fluorobenzylamine and phenylalanine methyl ester conjugates of 2-nitroimidazole: evaluation as hypoxic cell radiosensitizers. Int J Radiat Oncol Biol Phys. 1992;22(3):593-6. PubMed PMID: 1531220.
2. Bank U, Tadje J, T?ger M, Wolke C, Bukowska A, Ittenson A, Reinhold D, Helmuth M, Ansorge S, Shakespeare A, Vieth M, Malfertheiner P, Naumann M, Lendeckel U. Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-beta1 and ameliorates acute colitis in mice. Int J Mol Med. 2007 Oct;20(4):483-92. PubMed PMID: 17786278.
3. Nagai M, Kojima F, Naganawa H, Hamada M, Aoyagi T, Takeuchi T. Phebestin, a new inhibitor of aminopeptidase N, produced by Streptomyces sp. MJ716-m3. J Antibiot (Tokyo). 1997 Jan;50(1):82-4. PubMed PMID: 9066770.
4. Bukowska A, Tadje J, Arndt M, Wolke C, K?hne T, Bartsch J, Faust J, Neubert K, Hashimoto Y, Lendeckel U. Transcriptional regulation of cytosol and membrane alanyl-aminopeptidase in human T cell subsets. Biol Chem. 2003 Apr;384(4):657-65. PubMed PMID: 12751795.