TargetMol

Poloxin-2

Product Code:
 
TAR-T25969
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25969-5mg5mg£850.00
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TAR-T25969-50mg50mg£1,661.00
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Quantity:
TAR-T25969-100mg100mg£2,079.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Poloxin-2 is an effective Plk1 PBD inhibitor. It acts by inducing mitotic arrest and apoptosis in cultured human tumor cells at low micromolar concentrations.
CAS:
321695-37-8
Formula:
C18H22ClN5S
Molecular Weight:
375.91
Purity:
0.98
SMILES:
CC(C)CNC1=NC(NCC2=CSC(C3=CC=CC=C3)=N2)=NC=C1.[H]Cl

References

1. Scharow A, Knappe D, Reindl W, Hoffmann R, Berg T. Development of Bifunctional Inhibitors of Polo-Like Kinase 1 with Low-Nanomolar Activities Against the Polo-Box Domain. Chembiochem. 2016 Apr 15;17(8):759-67. doi: 10.1002/cbic.201500535. Epub 2015 Dec 4. PubMed PMID: 26634982. 2. Scharow A, Raab M, Saxena K, Sreeramulu S, Kudlinzki D, Gande S, D?tsch C, Kurunci-Csacsko E, Klaeger S, Kuster B, Schwalbe H, Strebhardt K, Berg T. Optimized Plk1 PBD Inhibitors Based on Poloxin Induce Mitotic Arrest and Apoptosis in Tumor Cells. ACS Chem Biol. 2015 Nov 20;10(11):2570-9. doi: 10.1021/acschembio.5b00565. Epub 2015 Aug 27. PubMed PMID: 26279064.