Probestin
| Code | Size | Price |
|---|
| TAR-T25987-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Probestin is an aminopeptidase M inhibitor, isolated from Streptomyces azureus MH663-2F6.
CAS:
123652-87-9
Formula:
C26H38N4O6
Molecular Weight:
502.612
Purity:
0.98
SMILES:
CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)=O
References
1. Pathuri G, Hedrick AF, Awasthi V, Ihnat MA, Gali H. Evaluation of 99mTc-probestin for imaging APN expressing tumors by SPECT. Bioorg Med Chem Lett. 2013 Sep 15;23(18):5049-52. doi: 10.1016/j.bmcl.2013.07.046. Epub 2013 Jul 29. PubMed PMID: 23937983.
2. Pathuri G, Madka V, Hedrick AF, Lightfoot SA, Awasthi V, Cowley BD Jr, Rao CV, Gali H. Evaluation of (99m)Tc-probestin SPECT as a novel technique for noninvasive imaging of kidney aminopeptidase N expression. Mol Pharm. 2014 Aug 4;11(8):2948-53. doi: 10.1021/mp5002872. Epub 2014 Jul 10. PubMed PMID: 24988047; PubMed Central PMCID: PMC4144757.
3. Pathuri G, Thorpe JE, Disch BC, Bailey-Downs LC, Ihnat MA, Gali H. Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor. Bioorg Med Chem Lett. 2013 Jun 15;23(12):3561-4. doi: 10.1016/j.bmcl.2013.04.031. Epub 2013 Apr 23. PubMed PMID: 23664876.
4. Pathuri G, Hedrick AF, Disch BC, Doan JT, Ihnat MA, Awasthi V, Gali H. Synthesis and evaluation of novel Tc-99m labeled probestin conjugates for imaging APN/CD13 expression in vivo. Bioconjug Chem. 2012 Jan 18;23(1):115-24. doi: 10.1021/bc200546b. Epub 2011 Dec 20. PubMed PMID: 22148582; PubMed Central PMCID: PMC3261373.