Pulvomycin
| Code | Size | Price |
|---|
| TAR-T26001-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Pulvomycin is a protein biosynthesis inhibitor preventing ternary complex formation between elongation factor Tu, GTP, and aminoacyl-tRNA.
CAS:
11006-66-9
Formula:
C47H66O13
Molecular Weight:
839.032
Purity:
0.98
SMILES:
CO[C@H]1[C@@H](C)O[C@@H](OC(C)C(O)C=CC=CC=CC(=O)C(C)C(O)C(C)C2CC=C/C=C/C=CC(O)C(=O)C(C)=C/C=CC(C)=C/C(O)C(C)=CCC(=O)O2)[C@H](OC)[C@H]1O
References
1. B?rding S, Bach T. An enantioselective synthesis of the C24-C40 fragment of (-)-pulvomycin. Chem Commun (Camb). 2014 May 18;50(38):4901-3. doi: 10.1039/c4cc01338g. PubMed PMID: 24691561.
2. Martucci NM, Lamberti A, Arcari P, Masullo M. The eubacterial protein synthesis inhibitor pulvomycin interacts with archaeal elongation factor 1? from Sulfolobus solfataricus. Biochimie. 2012 Feb;94(2):503-9. doi: 10.1016/j.biochi.2011.08.019. Epub 2011 Sep 10. PubMed PMID: 21924318.
3. Cammarano P, Teichner A, Chinali G, Londei P, de Rosa M, Gambacorta A, Nicolaus B. Archaebacterial elongation factor Tu insensitive to pulvomycin and kirromycin. FEBS Lett. 1982 Nov 8;148(2):255-9. PubMed PMID: 6759168.
4. Landini P, Bandera M, Soffientini A, Goldstein BP. Sensitivity of elongation factor Tu (EF-Tu) from different bacterial species to the antibiotics efrotomycin, pulvomycin and MDL 62879. J Gen Microbiol. 1993 Apr;139(4):769-74. PubMed PMID: 8515234.