Pyclen
| Code | Size | Price |
|---|
| TAR-T26002-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26002-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26002-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Pyclen is an inhibitor of cell death induced by oxidative stress and an inhibitor of AB1-40 aggregation induced by Cu2+ ion. It can both prevent and disrupt Cu(2+) induced AB(1-40) aggregation.
CAS:
78668-34-5
Formula:
C11H18N4
Molecular Weight:
206.293
Purity:
0.98
SMILES:
C1CNCc2cccc(CNCCN1)n2
References
1. Le Fur M, Beyler M, Lepareur N, Foug?re O, Platas-Iglesias C, Rousseaux O, Tripier R. Pyclen Tri-n-butylphosphonate Ester as Potential Chelator for Targeted Radiotherapy: From Yttrium(III) Complexation to (90)Y Radiolabeling. Inorg Chem. 2016 Aug 15;55(16):8003-12. doi: 10.1021/acs.inorgchem.6b01135. Epub 2016 Aug 3. PubMed PMID: 27486673.
2. Lincoln KM, Gonzalez P, Richardson TE, Julovich DA, Saunders R, Simpkins JW, Green KN. A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders. Chem Commun (Camb). 2013 Apr 4;49(26):2712-4. doi: 10.1039/c2cc36808k. PubMed PMID: 23437435; PubMed Central PMCID: PMC4446701.
3. Lincoln KM, Richardson TE, Rutter L, Gonzalez P, Simpkins JW, Green KN. An N-heterocyclic amine chelate capable of antioxidant capacity and amyloid disaggregation. ACS Chem Neurosci. 2012 Nov 21;3(11):919-27. doi: 10.1021/cn300060v. Epub 2012 Aug 31. PubMed PMID: 23173072; PubMed Central PMCID: PMC3503443.
4. Lincoln KM, Offutt ME, Hayden TD, Saunders RE, Green KN. Structural, spectral, and electrochemical properties of nickel(II), copper(II), and zinc(II) complexes containing 12-membered pyridine- and pyridol-based tetra-aza macrocycles. Inorg Chem. 2014 Feb 3;53(3):1406-16. doi: 10.1021/ic402119s. Epub 2014 Jan 17. PubMed PMID: 24437677.