RH 3421
| Code | Size | Price |
|---|
| TAR-T26070-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
RH 3421 is used as a neuroactive dihydropyrazole insecticide.
CAS:
99832-61-8
Formula:
C20H17ClF3N3O3
Molecular Weight:
439.82
Purity:
0.98
SMILES:
COC(=O)C1(C)CN(N=C1c1ccc(Cl)cc1)C(=O)Nc1ccc(cc1)C(F)(F)F
References
1. Nicholson RA, Williams MF. Sub-chronic administration of ethanol to mice does not modify the inhibitory effects of dieldrin, abamectin and the dihydropyrazole RH-3421 at their respective sites of action in the nervous system. Comp Biochem Physiol C. 1993 May;105(1):69-72. PubMed PMID: 7687943.
2. Tsurubuchi Y, Zhao X, Nagata K, Kono Y, Nishimura K, Yeh JZ, Narahashi T. Modulation of tetrodotoxin-resistant sodium channels by dihydropyrazole insecticide RH-3421 in rat dorsal root ganglion neurons. Neurotoxicology. 2001 Dec;22(6):743-53. PubMed PMID: 11829408.
3. Zhang A, Nicholson RA. RH-3421, a potent dihydropyrazole insecticide, inhibits depolarization-stimulated rises in free [Ca2+] and 45Ca2+ uptake in mammalian synaptosomes. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1994 Jul;108(3):307-10. PubMed PMID: 7881802.
4. Silver K, Soderlund DM. State-dependent block of rat Nav1.4 sodium channels expressed in xenopus oocytes by pyrazoline-type insecticides. Neurotoxicology. 2005 Jun;26(3):397-406. PubMed PMID: 15935211.