Rhizoxin
| Code | Size | Price |
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| TAR-T26076-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Rhizoxin is an antitumor drug isolated from the fungus Rhizopus chinensis. It is a macrocyclic lactone compound that binds to tubulin and inhibits microtubule assembly.
CAS:
90996-54-6
Formula:
C35H47NO9
Molecular Weight:
625.759
Purity:
0.98
SMILES:
[H][C@]12C[C@@]3([H])CC(=O)O[C@]([H])(C3)[C@H](C)C=C[C@@]3([H])O[C@]3(C)[C@@H](O)C[C@H](OC(=O)[C@]1([H])O2)[C@H](C)[C@@H](OC)C(C)=CC=CC(C)=Cc1coc(C)n1
References
1. Takeuchi K, Noda N, Katayose Y, Mukai Y, Numa H, Yamada K, Someya N. Rhizoxin analogs contribute to the biocontrol activity of a newly isolated pseudomonas strain. Mol Plant Microbe Interact. 2015 Mar;28(3):333-42. doi: 10.1094/MPMI-09-14-0294-FI. PubMed PMID: 25496595.
2. McLeod HL, Murray LS, Wanders J, Setanoians A, Graham MA, Pavlidis N, Heinrich B, ten Bokkel Huinink WW, Wagener DJ, Aamdal S, Verweij J. Multicentre phase II pharmacological evaluation of rhizoxin. Eortc early clinical studies (ECSG)/pharmacology and molecular mechanisms (PAMM) groups. Br J Cancer. 1996 Dec;74(12):1944-8. PubMed PMID: 8980394; PubMed Central PMCID: PMC2074819.
3. Kusebauch B, Brendel N, Kirchner H, Dahse HM, Hertweck C. Assessing oxazole bioisosteres as mutasynthons on the rhizoxin assembly line. Chembiochem. 2011 Oct 17;12(15):2284-8. PubMed PMID: 23106078.
4. Takahashi M, Iwasaki S, Kobayashi H, Okuda S, Murai T, Sato Y. Rhizoxin binding to tubulin at the maytansine-binding site. Biochim Biophys Acta. 1987 Dec 7;926(3):215-23. PubMed PMID: 3120782.